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Of particular note is that in studies HGH fragment 176-191 had the ability to increase muscle growthin young, trained males, including the same men at a high enough dose to allow for possible enhancement of fat-free mass. The subjects at the highest dose in this group gained no more weight as total body fat increased. The subjects at the high dose in this group also had the largest percent change in the total waist circumference, body fat, and muscle mass (all as measured by MRI). No significant difference in percentage of body fat change (in the upper or lower limbs) was observed between the higher dose groups [20,21]. A higher dose in obese women showed even greater increases in lean body mass as fat-free mass did. In total, these data show that HGH or recombinant human GH enhances muscle growth in young overweight men, a phenomenon that has been well documented in animal models [22]. Finally, it will be noted that HGH does not increase levels of circulating testosterone and doesn't change the circulating levels of estradiol (the primary hormone controlling body weight [23]). Studies in the 1990s and 2000s have demonstrated that an acute injection of recombinant GHRH (or recombinant human growth hormone) in men increased testosterone levels to levels comparable to what would typically be seen after a low dose of testosterone. However, studies in the 2000s have shown that high doses of HGH and high doses of testosterone do not interfere with the body's ability to use estradiol as a progesterone [24]. Thus, in most situations HGH isn't capable of interfering with hormones that regulate body weight. With the increasing availability of GH as a treatment for obesity, it would be interesting to perform studies to determine whether HGH and testosterone do modify the hypothalamic-pituitary system or if both do. In summary, it appears that HGH is safe and effective for use in the treatment of men with obesity. Similar articles:

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